Gamete intrafallopian transfer (GIFT) and zygote intrafallopian transfer (ZIFT) are two methods used to help a woman become pregnant. With GIFT, sperm and eggs are put in the fallopian tube. With ZIFT, the sperm and egg are first combined in a lab. Then a fertilized egg is put into the fallopian tube.

Front view cross section of female reproductive tract showing instrument injecting sperm and eggs into fallopian tube.
With GIFT, sperm and eggs are placed in a fallopian tube to allow fertilization in the natural site. The woman must have at least one normal, open fallopian tube.

Why GIFT and ZIFT are used

GIFT and ZIFT can help produce a pregnancy when some health problems are present. These include:

  • Mild endometriosis and sperm antibodies in a woman

  • Low sperm production in a man

  • Unexplained infertility

Getting ready for GIFT or ZIFT

  • Medicine is used to stimulate the ovaries. This causes them to make many mature eggs.

  • The eggs are removed from the ovaries with a thin needle. This is typically done through the vagina.

Hormone treatment with GIFT or ZIFT

GIFT or ZIFT may be used along with hormone treatment. This can improve the chance of a pregnancy. Your healthcare provider can talk with you about the details, success rates, and costs.

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